Leflunomide

Introduction

Leflunomide is a disease-modifying antirheumatic drug (DMARD) used to treat autoimmune conditions such as rheumatoid arthritis and psoriatic arthritis. It helps reduce inflammation, slow joint damage, and improve physical function. Leflunomide works by suppressing the immune system to prevent it from attacking healthy joints. It is usually prescribed when other treatments like methotrexate are not suitable or effective. This medication is available in tablet form and is typically taken once daily. Regular monitoring is necessary to ensure its safe and effective use.

Uses of Leflunomide

• Treatment of rheumatoid arthritis
• Management of psoriatic arthritis
• Reduces joint pain and swelling
• Prevents further joint damage
• Improves mobility and quality of life

How Leflunomide Works

Leflunomide works by inhibiting an enzyme called dihydroorotate dehydrogenase, which is essential for the production of DNA in immune cells. By reducing the activity of overactive immune cells, it helps decrease inflammation and prevents joint damage. This action slows the progression of autoimmune conditions like rheumatoid arthritis and psoriatic arthritis, providing relief from pain and swelling.

Benefits of Leflunomide

• Reduces inflammation and swelling in joints
• Prevents joint damage and deformity
• Improves movement and overall quality of life
• Effective for long-term management of autoimmune arthritis
• Can be used when other treatments are not suitable

How to Take Leflunomide

Leflunomide is usually taken once daily, with or without food. The dosage is determined by a doctor based on the patient`s condition. A higher loading dose may be given initially to build up the drug levels in the body. Patients should take the tablet whole with water and avoid alcohol while on this medication. Regular blood tests are required to monitor liver function and white blood cell count.

Types of Dosage Available

• Leflunomide 10 mg tablets
• Leflunomide 20 mg tablets
• Leflunomide 100 mg tablets (loading dose)

Side Effects of Leflunomide

• Nausea and diarrhea
• Headache and dizziness
• Elevated liver enzymes
• Hair thinning or hair loss
• Increased risk of infections
• Skin rash or allergic reactions
• High blood pressure

Safety Advice

• Do not take Leflunomide during pregnancy or breastfeeding
• Avoid alcohol to prevent liver damage
• Regular liver function tests are necessary
• Use effective birth control while taking this medication
• Inform your doctor if you experience any unusual symptoms
• Do not take live vaccines while on Leflunomide